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M3 C400389= 1>;>= 402B0= 9;G8;AM= F>G@CC;K= =;3@ AAM= 5@=E89 40A0= 7>E8F;K= E0< H8=689= 54 (!5;L5389EMM@) 70EK= FCA0= 40EL =59B@>D8;89= B>> O;8<39 >;H8@G, ;8<D>F8B, M>78=>D8;89= B>> F@43 134 OA=K G<3= 4ME ;8<D>F8BK= B>> >;H8@G, 185 39FAM= <E;3B MA489= B>> 1030A403. %0@8= 40@E;00=K M@EBM=4 4ME MA89= B>> EM<6MM 1CC@403 109=0. =3M6 OA=K G<3= 4ME 185 39FAM= <E;3B MA89= B>> 1>;>= 40@E;00=K M@EB=4 4ME MA89= B>> 1CC@0E =L M43MM@ MA4 70EK= FCA0=4 >@>E 9; O2F B@3MAAM=BM9 E>;1>>B>9 @@ EM;1M;, OA=K G<3= 4ME <E;3B MA4 1>;>= AM@MM 1C;G8@E09, 4M;= 4ME 40@E;00 G040<6B09 MA489= =F =L AB@5AA89= C;<00A 70EK= FCA0=4 1030AA0= MA4893 =E6 343 109=0. &00H84 40A0= 7>E8F;K= 54 OA=K G<3= 4ME FCA AM;B89= 38?5@?;078 1>;6, O;0=3CO0 <E;3B MA89= M3=MM=89 70;CC MA489= B>> >;H8@G, C;<00@ <E;3B MA89= AM;B893 7>E8FCC;=0. !B@5AA F>G@CC;K= 9;G;M; @3M;68;AM= B>E8>;4>;4 AB@5AA89= 3-@ 5 1CNC BC9;4;K= 54 >@=>. !B@5AA F>G@CC;K= =;3@ FCA=K B>3B>;F>>=4 30@G 1C9 M43MM@ C@20; =L AB@5AA B>3B>;F>>=K 04@5=4 <M4@M3 1>;>= 38?>B0;0<CA-=G8= B0@E8-1@=89 4MM4 1C;G8@E09= E>;B>A;>3 402E0@30 84M2E6AM=BM9 E>;1>>B>9. 0@E;00=K M@EB=4 1>;>= BC=30;389= 70=38;00=CC4 =L A8<?0B8: <M4@M;6;M;BBM9 109403. 0EK= FCA0= 40EL =59B@>D8;, OA=K G<3= 4ME 40@E;00 G040<6B09 MA489= B>> 8EAM6 1C9 10940; =L 1@=89 4MM4 1C;G8@E09= E>;B>A;>3 402E0@3K= 4002@00A E0<00@0;393MM@ :0B5E>;0<8=, (-04@5=4 <M4@M3 E;MM= 02CC@00@ 7>E8FCC;034403. !B@5AA89= 54 4M;= 4ME MA489= B>> EM<6MM 1030A403 =L 04@5=<M4@M3 B>3B>;F>> 84M2E686, :0B5E>;0<8=K =;3@ 3;3@ 1C;G8= 03H86 C;<00@ 68683 EM<6MMBM9 ;8<D>F8BCC4 30@403B09 E>;1>>B>9. @@ EM;1M; "-;8<D>F8BK3 1>42>; 8; B>< EM<6MMBM9 -;8<D>F8B 8EMM@ O;30@0= 30@G, 4M;=4 "-;8<D>F8BK= B>> EM<6MM @G;346, "-;8<D>F8B4 4M;=MMA O;30@0= 30@=0. 9< 1094;00@ AB@5AA89= 54 4M; =L  O0@0;B09 BCA;0<6 -89= @3893 39FMB3M6, O=7 1@89= EM;1M@89= 40@E;00=K MA4893 FCA0=4 >@CC;=0. !B@5AA89= 54 AM@MM 1C;G8@E09 40EL 40@E;00=K MA489= B>> EM<6MM 1030A06, 1@ 39 1>;>E =L 38?>B0;0<CA-=G8= B0@E8-1@=89 4MM4 1C;G8@E09= E>;B>A;>3 402E0@3K= 4002@K= O;30@0; 8EMAAM=BM9 E>;1>>B>9. @=89 4MM4 1C;G8@E093 B09@A0= 54 MA2M; 38?>:>@B8F87<K= 54 AB@5AA A3MEM4 B8<>F8B>>A E0<00@0E393MM@ "-MA 3;N:>:>@B8:>84 40020@B EMB <M4@M3 1>;4>3. -=4MMA AM@MM 1C;G8@E09300A B8<>F8B O;30@0= 30@0E =L =8;MM4 E>6CC 1CNC 1-2 E>=>389= 40@00 O2034403. %0@8= 4M;=89 9; 068;;0300=K 4CB<03H8;K= 54 AM@MM 1C;G8@E09= 9; 068;;0300 B@3MAM6, AB@5AA F>G@CC; 9;G8;6 MEM;AM= ME=89 F0300A ME;M= ;8<D>F8BK= ME A2M@ 1>;4>3 109=0. !B@5AA C@20;K= 54 ;8<D>F8B F@E =L 70EK= FCA=00A 40@E;00=K MA4 =4M;;ME 9; O2F B@3MAAM=BM9 E>;1>>B>9 109403. -=M =4M;;ME 9; O2F =L <= OA=K G<3=4 O20340E 134 =MMA @ EM4 EM4M= H0;B300=K C;<00A OA=K G<3=4  ;8<D>84K= >@38; 5 1>;=>. -=M =L <= (-04@5=4 <M4@M3 E;MM= 02CC@, 04@5=4 <M4@M3 B>3B>;F>>=K =;3@ O20340E 134 AB@5AA F>G@CC;K= =;3@ OA=K G<3= 4ME 40@E;00=K MA489= 03CC;0<6 8EAME =L OA=K G<3=89 40@E;00B G0=0@K3 8EMA3M=M. &CA=00A 40@E;00=K MA4 1CA04 1BMF @ 1CNC BC=30;389= 70=38;00=4 =4M;;M= >G86 40@E;00=K E0@8C C@20; 7;MEM4 1M;M= 10940;4 >@=>."=G;M= @ M@EBM= @ G =4M;;ME 9; O2F O2034403 109=0. "C=30;0389= B>3B>;F>> =L 40@E;00=K 9; 068;;03003 E0=30EK= 7M@M3FMM M4 M@EB=89 =E= B;68;B89= 7>E8FCC;30=4 HCC4 1CA 70<00@ >@>;F>=>. @E=89 1C;G8=, M;M3, 1@=89 M4893 EMAM3G;M= 02A0= 54 ;8<D>F8B =L M43MM@ M@EB=89 =E= B;68;B=4 >@>;F4>3 134 40@E;00=K MA489= 4CB034;K= 54 =E= B;68E 84M2E 8;B 1CC@403 109=0. =3M6 AB@5AAK= 54 FCA=K B>3B>;F>> =L 40A0= 7>E8F>E F>3F 9; 068;;03003 39FMB3M6, 40@E;00 B>3B>;F>>3 84M2E6;MEM4 =;;43 109=0. !B@5AA F>G@CC; C400= EC30F00300@ 9;G8;A=MMA FCA=K B>3B>;F>>=K 9; 068;;0300=K 84M2E 1CC@G, C;<00@ 40@E;00 40@0=3C9;03406 40@E;00=K M<3M3 AMEM4 E@=M. 8HMM =L: E0@E0=4 E89AM= BC@H8;B00A E0@0E04, C400= EC30F00300@ @3M;68;AM= 24;B89= =;3@ /4@B 3-6 F0300@, 14-18 E>=>3/ 70EK= FCA0= 40EL F0300= MA89= =89B B>> 20%-80@, =59B@>D8; 20%-80@, M>78=>D8; 70%-80@, ;8<D>F8B 27%-80@, <>=>F8BK= B>> 2.5 40E8= 1CC@A0=. %0@8= M@8B@>F8BK= B>> @G;3439 109=0. -=M 54 OA=K G<3=4 70;CC MA489= =89B B>> 1030A06, 1E EM;1M@89= MA489= B>> 4C=4600@ 28-68%-80@ (=59B@>D8;89= ?@><85;>F8B, <85;>F8B, <5B0<85;>F8B) BCA BCA 1CC@403 109=0. %0@8= 4M;=89 MA89= B>> >=FK= @G;;B39, AM@MM 1C;G8@E09 40EL B8<>F8BK= B>> EM289= EM<6MM=MMA 4>>H 40% E@BM; EM<6MMBM9 1CC@A0= 109=0. !B@5AA89= 54 40@E;00 B>3B>;F>>=4 30@0E @G;;B 0@E;00 B>3B>;F>> =L AB@5AA B>3B>;F>> 1>;>= AB@5AA893 B>3B>;F>>B>9 =O3B E>;1>>B>9 134 40@E;00 B>3B>;F>>=K 7>E8FCC;3K= B2 0??0@0B =L <M4@M;89= 7>E8FCC;3K= 0??0@0BK= 3>; EMAM3B 109@;0403 38?>B0;0<CA, 38??>:0<?, 39;AM= 1854 109@;0403 CG8@ 40@E;00 B>3B>;F>> =L AB@5AA A3M3G EG8= 79;89= E0@8C4 B@3M= EC30F00=4 E0@8C 9;4M; 7;MEM4 >@>;F>=>. -43MM@ =L E>>@>=4>> B0A;02G 1>;>= 59=5@BK= ACC@89= 1<89= E>;8=4 <M4@M3 =59@>=, EE B>;1>=K =>@04@5=0;8=4 <M4@M3 =59@>=, <57>;8<1 1>;>= =83@>AB@80BC<K= B>3B>;F>>=K 4>D0<8=4 <M4@M3 =59@>=, A;B 1<89= 30<<00<8=B>A=K EG;89= =59@>=, >Q4;K= 1<89= A5@>B>=8=4 <M4@M3 =59@>=CC400@ BCA BCA E>;1>344>3 109=0. 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a Silva JAP. 1999. Sex hormones and glucocorticoids: interactions with the immune system. Ann N Y Acad Sci; 876:102 [Abstract/Free Full Text] Nicolas Rohleder, Nicole C.S 2001. Sex Differences in glucocorticoid sensitivity of proinflammatory cytokine production after psychosocial stress. Psychosomatic medicine USA; 5; pp 6-11 Ivan V. Shirinsky. 1996. Social stress disorders and immunity. Russ.Med. J, 3, pp689-695 Hunter.E, Kathryn L.McCance. 2000. Stress and Desease. Understanding pathophysiology. p.221-232 Nicholas P.Jewell. 2004. 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